Nodules as small as 1-2 mm in diameter can be detected by HRCT. Nodules can be classified according to their appearance such as well-defined (likely interstitial) or ill-defined (likely air-space) or classified according to their distribution in relation to other lung structures (i.e. perilymphatic, random, or centrilobular).
Perilymphatic nodules are usually well-defined and occur in relation to the lymphatics. They often affect the pleural surfaces and the peribronchovascular, interlobular septa, and centrilobular interstitial components.
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